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Non-Invasive Ventilation and prevention of Ventilator-Associated Pneumonia

Dr Barbara Miles on behalf of the SICS EBM Group.

Consultant, Intensive Care Unit, Stobhill Hospital, Glasgow

Correspondence to: barbara.miles.stob@northglasgow.scot.nhs.uk

 SICS EBM web site December 2004

Citation: EBM Reviews. Scottish Intensive Care Society EBM Group. Miles B. Non-Invasive Ventilation and prevention of Ventilator-Associated Pneumonia. 2004. 

Non-invasive ventilation has been an intervention considered in several RCTs, some of which have included VAP as an outcome. These studies involved a heterogeneous mix of patients and it seems unwise to group them together for analysis. However each is worthy of consideration: 

RCT of NIV in acute respiratory failure: 

Massimo Antonelli, Giorgio Conti et al: A comparison of noninvasive positive pressure ventilation and conventional mechanical ventilation inpatients with acute respiratory failure. NEJM 1998; 339:429-435. CAT.

RCT of NIV in COPD:

Laurent Brochard, Jordi Mancebo et al: Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. NEJM 1995; 333:817-22. CAT.

RCT of NIV in immunosuppressed: 

Gilles Hilbert, Didier Gruson et al: Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever and acute respiratory failure. NEJM 2001;344:481-7. CAT.
 

RCT of NIV in acute respiratory failure after solid organ transplantation:

Massimo Antonelli, Giogio Conti et al: Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation. JAMA 2000; 283:235-241. CAT.

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© SICS EBM Group 2004